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Joseph A Toonen Selected Research

Optic Nerve Glioma

8/2017Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature.
4/2017Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma.
1/2017Defining the temporal course of murine neurofibromatosis-1 optic gliomagenesis reveals a therapeutic window to attenuate retinal dysfunction.
1/2017Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma-induced retinal pathology.
1/2016NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1.
10/2015RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth.
6/2015Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.
5/2015The impact of coexisting genetic mutations on murine optic glioma biology.

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Joseph A Toonen Research Topics

Disease

8Optic Nerve Glioma
08/2017 - 05/2015
5Neoplasms (Cancer)
08/2017 - 06/2015
4Glioma (Gliomas)
08/2017 - 06/2015
2Neurofibromatosis 1 (Neurofibromatosis Type I)
08/2017 - 06/2015
1Astrocytoma (Pilocytic Astrocytoma)
08/2017
1Vision Disorders (Hemeralopia)
01/2017
1Brain Neoplasms (Brain Tumor)
10/2015

Drug/Important Bio-Agent (IBA)

3Retinaldehyde (Retinal)IBA
01/2017 - 05/2015
2RNA (Ribonucleic Acid)IBA
08/2017 - 10/2015
1Sirolimus (Rapamycin)FDA Link
08/2017
1Minocycline (Cyclops)FDA LinkGeneric
08/2017
1Carboplatin (JM8)FDA LinkGeneric
08/2017
1Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA
04/2017
1Proteins (Proteins, Gene)FDA Link
04/2017
1Metalloproteases (Metalloproteinases)IBA
04/2017
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
04/2017
1Gonadal Steroid Hormones (Sex Hormones)IBA
01/2017
1Estrogens (Estrogen)FDA Link
01/2017
1Biomarkers (Surrogate Marker)IBA
01/2017
1Glial Fibrillary Acidic ProteinIBA
01/2016
1NeomycinFDA LinkGeneric
01/2016
1ChemokinesIBA
10/2015
1CC ChemokinesIBA
10/2015
1LigandsIBA
10/2015
1Neutralizing AntibodiesIBA
10/2015
1MitogensIBA
10/2015
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2015
1TOR Serine-Threonine KinasesIBA
06/2015
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
06/2015
1Neurofibromin 1 (Neurofibromin)IBA
06/2015
1Biological ProductsIBA
05/2015

Therapy/Procedure

4Therapeutics
08/2017 - 06/2015
2Drug Therapy (Chemotherapy)
08/2017 - 01/2017
1Traction
08/2017